ретиноевая мазьToday in medicine and the beauty industry uses a variety of retinoids for topical use: retinol, tretinoin, adapalene, tazarotene, alitretinoin and bexarotene. One of the most popular tools is retinoic retinoic ointment that can be bought in almost any pharmacy.

About the special efficacy of vitamin a and its derivatives in the elimination of acne, psoriasis and the first signs of skin aging was first discussed in 1971. Retinoids are chemical derivatives of vitamin A, these substances effectively influence intercellular processes, stimulates the growth of epithelial cells and the proliferation rate.

Retinoic ointment is prescribed to treat mild forms of acne and at the initial stage of acne. The ointment should be applied to cleansed face for 20-30 minutes twice a day.


The mechanism of action of retinoids

The mechanism of action of retinoids on skin cells is quite complicated and describe it in few words is impossible. External use retinoids the most positive impact on increasing the level of collagen in skin cells. Among retinoids topical applications the most powerful is considered to be tretinoin that is widely used to eliminate the signs of so-called photoaging, i.e. aging of the skin caused by harmful UV rays. Other retinoids have also been shown to be quite effective in preventing skin aging from sunlight. This protection mechanism is primarily associated with the interaction of retinoic acid with retinoid X receptors in the nucleus of cells. These receptors increase the production of procollagen and inhibits the release of mediators of inflammation.

Retinoids topical applications, in addition to all the other things work as well as comedolytic agents, i.e. substances, purifying clogged skin grease and dust the pores of the skin. In synergetic tandem with topical antibiotics retinoids help the latter to penetrate deeper into the skin pores and destroy the bacteria that cause inflammation and, as a result, the occurrence of acne. In most cases recondi local applications are assigned to the medical patients with mild forms of acne.

Retinoids are used not only in inflammatory processes of the skin, but also in disorders of pigmentation caused by melasma, lentigo or inflammation. Retinoic ointment is prescribed as an independent therapy, in the form of a component of complex treatment.

Psoriasis retinoids shown to reduce hyperproliferative and exfoliate the top layer of skin cells.

Psoriasis treatment with retinoic ointment and other topical agents with a content of retinoid helps to eliminate inflammation and restore a picture of pigment of the skin, that is as to nullify the difference between the unaffected psoriatic epidermis and psoriatic plaques. Research on the effectiveness retinoidov in the treatment of psoriasis continue in our days, scientists are trying to establish a more precise mechanism of action of these substances on cells depending on one or another skin problems.

So, for the treatment of acne, follicular keratosis, prevention and elimination of fine lines and hyperpigmentation applied retinol and tretinoin. Adapalene – izluchatelya component zit. Tazarotene indicated for acne and psoriasis. Alitretinoin prescribed for the treatment of Kaposi’s sarcoma, and bexarotene use in the therapeutic treatment of cutaneous T-cell lymphoma.


Side effects and contraindications when applying retinoids

Side effects in most cases can occur when excess dosage and too long-term use of topical medication with retinoids. The most common side effects of retinoids are the following States:

  • Excessive dryness of the skin
  • Redness and peeling
  • Skin itching
  • Less common side effects such as:
  • Pigmentation disorders
  • Hypersensitivity to UV light
  • Sudden exacerbation of acne
  • The exacerbation of eczema
  • Swelling
  • The formation of blisters and severe burning sensation

Retinoic ointment and other preparations containing retinoids can be administered to pregnant women to treat acne, but only in cases if the level of benefit that they will bring the mother far exceeds the risk of adverse effects of the drug on the unborn baby.

During pregnancy retinoids is not recommended to use to eliminate wrinkles, hyperpigmentation and dryness of the skin.

The effectiveness of retinoic ointment depends on the individual characteristics of the organism and the combination of retinoids with other agents that can be used in the treatment of a problem. The local application of retinoids should be strictly follow the physician’s recommendations and in no case to prevent overdose, overdose is the cause of most side effects. If after the application of retinoic ointment you notice any of these side effects, be sure to seek help from a specialist.

In pharmacies and departments of supermarkets, you can find creams and gels with the content of retinoids. There are so many brands that produce retinoic ointment and other products containing retinoids under various names.

  • Ointment ReTrieve™ contains tretinoin
  • Cream Retin-A™ contains tretinoin and retinoic acid
  • Ointment or cream Retinova™ Cream with tretinoin
  • Isotrex gel™ Gel with isotretinoin
  • Differin™ in the form of a gel or cream containing adapalene
  • Gel Epiduo® combination adapalene, and benzoyl peroxide.

When treating acne , the effectiveness of retinoids, you may notice after a few weeks of use, but the really noticeable changes can be assessed no earlier than six weeks and more. The ability of retinoids to regulate the process of pigmentation is often used in the production of whitening creams and ointments. Retinoids topical applications can be applied to any part of the body, but as a rule, most of these ointments are used for skin treatment of face, neck or back.

Retinoids possess mild exfoliating properties, removing thin layer of cells, retinoic creams can affect the skin’s sensitivity to UV light, thereby increasing the risk of sunburn. Skin irritation may worsen the environment, wind, cold, aggressive detergents, soap, the wrong type of skin care and decorative cosmetics.

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